Curriculum Vitae: Hideki Taguchi

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1993: Ph.D. in Biochemistry, Tokyo Institute of Technology, Japan
Dissertation title: Studies on a Molecular Mechanism of Chaperonin
Supervisor: Prof. Masasuke Yoshida
1991: M.S. in Biochemistry, Tokyo Institute of Technology, Japan
1989: B.S. in Organic chemistry, Tokyo Institute of Technology, Japan



2016-present: Professor, Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
2010-2016: Professor, Graduate School of Biosciences and Biotechnology, Tokyo Institute of Technology
2003-2010: Associate Professor, Graduate School of Frontier Sciences, University of Tokyo
1995-2003: Assistant Professor, Chemical Resources Laboratory, Tokyo Institute of Technology

1993-1995: Postdoctoral Fellow, Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship at Chemical Resources Laboratory, Tokyo Institute of Technology

1994 Seiichi Tejima Doctoral Dissertation Award, 2013 Seiichi Tejima Paper Award, 2019 Seiichi Tejima Paper Award, 2019 Seiichi Tejima Book Award, 2019 Best Teacher Award

Selected Publications
1. Miwa T, Chadani Y, *Taguchi, H. Escherichia coli small heat shock protein IbpA is an aggregation-sensor that self-regulates its own expression at post-transcriptional levels. Mol Microbiol (2020)
2. Konno H, †Watanabe-Nakayama T, Uchihashi T, Okuda M, Zhu L, Kodera N, Kikuchi Y, *Ando T, *Taguchi, H. † equally contributed authors Dynamics of oligomer and amyloid fibril formation by yeast prion Sup35 observed by high-speed atomic force microscopy. Proc Natl Acad Sci USA 117, 7831-7836 (2020)
3. Chadani Y, Niwa T, Izumi, T., Sugata, N., Nagao, A., Suzuki, T., Chiba S, *Ito K. and *Taguchi, H. Intrinsic ribosome destabilization underlies translation and provides an organism with a strategy of environmental sensing. Mol Cell 68, 528-539 (2017)
4. Chadani Y, Niwa T, Chiba S, *Taguchi, H, *Ito K. Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing. Proc Natl Acad Sci USA 113, E829-38 (2016)
5. Okuda, M, Niwa, T., Taguchi, H.* Single-Molecule Analyses on the Dynamics of Heat Shock Protein 104 (Hsp104) and Protein Aggregates. J. Biol. Chem. 290, 7833-7840 (2015)
6. Ishimoto, T., Fujiwara, K., Niwa, T., Taguchi, H.* Conversion of a chaperonin GroEL-independent protein into an obligate substrate. J. Biol. Chem. 289 32073-32080 (2014)
7. Niwa, T., Kanamori T., Ueda, T.*, Taguchi, H.* Global Analysis of Chaperone Effects Using a Reconstituted Cell-Free Translation System. Proc Natl Acad Sci USA 109, 8937-8942 (2012)
8. Kawai-Noma, S., Pack, C-G., Kojidani, T., Asakawa, H., Hiraoka, Y., Kinjo, M., Haraguchi, T., Taguchi, H.*, and Hirata, A. In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells. J. Cell Biol. 190, 223-231 (2010)
9. Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T. and Taguchi, H.* A systematic survey of in vivo obligate chaperonin-dependent substrates. EMBO J. 29, 1552-1564 (2010)
10. Niwa, T., Ying, B.-W., Saito, K., Jin, W. Z., Takada, S., Ueda, T.* and Taguchi, H.* Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of Escherichia coli proteins. Proc Natl Acad Sci USA 106, 4201-4206 (2009)
11. Ueno, T.#, Taguchi, H.#, Tadakuma, H., Yoshida, M., Funatsu, T. [# equally contributed] GroEL mediates protein folding with a two successive timer mechanism. Mol Cell 14, 423-434 (2004)
12. Taguchi, H., Ueno, T., Tadakuma, H., Yoshida, M., Funatsu, T. Single-molecule observation of protein-protein interactions in the chaperonin system. Nat Biotechnol. 19, 861-865 (2001)


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